Rationale
In patients with hypocalcemia, tetany and/or seizures may develop, particularly if the onset is acute. Severe or prolonged hypercalcemia may cause irreversible end-organ damage and may be life-threatening.
Causal Conditions
(list not exhaustive)
- Hypocalcemia
- Loss of calcium from the circulation
- Hyperphosphatemia (e.g., renal insufficiency)
- Pancreatitis
- Osteoblastic metastases
- Drugs (e.g., ethylenediaminetetraacetic acid [EDTA])
- Rhabdomyolysis
- Decreased vitamin D production or action
- Kidney injury
- Rickets
- Malabsorption
- Neonatal
- Decreased parathyroid hormone production or action
- Postoperative (e.g., postparathyroidectomy)
- Autoimmune
- Diminished response
- Low magnesium
- Loss of calcium from the circulation
- Hypercalcemia
- Increased intestinal absorption
- Increased intake (e.g., milk-alkali syndrome)
- Vitamin D mediated (e.g., sarcoidosis)
- Increased bone resorption
- Malignancy
- Hyperparathyroidism
- Hyperthyroidism
- Immobilization
- Diminished excretion (e.g., diuretics)
- Increased intestinal absorption
Key Objectives
Given a patient with either hypocalcemia or hypercalcemia, the candidate will diagnose the cause, severity, and complications and will initiate an appropriate management plan.
Enabling Objectives
Given a patient with hypocalcemia, the candidate will
- list and interpret critical clinical findings, including
- differentiation between hypocalcemia related to renal disease and hypocalcemia due to other causes; and
- signs and symptoms of tetany;
- list and interpret critical clinical investigations, including
- ionized calcium and/or total calcium levels corrected for albumin to assess severity; and
- phosphate, magnesium, parathyroid hormone, and vitamin D levels and renal function assessment; and
- construct an effective initial management plan, including
- administering intravenous calcium if the patient has symptomatic hypocalcemia; and
- determining whether the patient needs specialized care.
Given a patient with hypercalcemia, the candidate will
- list and interpret critical clinical findings, including
- differentiation between hypercalcemia caused by malignancy and hypercalcemia due to other causes;
- volume status of the patient; and
- common physical examination findings associated with hypercalcemia;
- list and interpret critical clinical investigations, including
- ionized calcium and/or total calcium levels corrected for albumin to assess severity; and
- laboratory and imaging investigations to determine the causal condition(s); and
- construct an effective initial management plan, including
- administering fluid resuscitation with or without medications if the patient has severe hypercalcemia; and
- determining whether the patient needs specialized care.